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Retatrutide is a triple agonist (GLP-1, GIP, and glucagon receptors), which makes it considerably more powerful than semaglutide or even tirzepatide

The highest concentrations are found in animal sources, such as meat, dairy, fish and eggs

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Structurally, PPDK is an ATP-grasp protein composed of three distinct domains: an N-terminal ATP-binding domain, a central kinase domain (containing a catalytic histidine) and a C-terminal pyruvate/PEP binding domain