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Beyond appetite suppression, semaglutide improves metabolic efficiency by enhancing insulin secretion and reducing liver fat accumulation

Furthermore, mTG stimulates protein cross-linking that may act as novel immunogenic epitopes and induce inflammation (Lerner and Matthias 2015a)

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Recent studies have highlighted the up-regulation and necessity of one-carbon metabolism for tumor cell proliferation, thus making this metabolic pathway a viable therapeutic target (see Chandel 2020b)