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Colombijn JMT, de Leijer JF, Visseren FLJ et al (2025) Effectiveness and safety of combining SGLT2 inhibitors and GLP-1 receptor agonists in individuals with type 2 diabetes: a systematic review and meta-analysis of cohort studies

If symptoms are severe, discuss with your provider whether a slightly lower dose or slower titration might reduce discomfort while still achieving your weight loss goals

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Berk M, Bodemer W, van Oudenhove T, Butkow N

Second, synaptic remodeling in animal models unfolds over days of repeated dosing and task training, not minutes