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doi: 10.1073/pnas.77.6.3384

An open-label study (n=42) found that IV NAC (50 mg/kg) combined with oral NAC (500 mg twice daily) for 3 months increased brain glutathione levels (measured by MRS), increased dopamine transporter binding (measured by DaTscan), and improved UPDRS motor scores (Monti et al., PLoS One, 2016) [53]

These apparently less anxious behavioral features could also be explained by stress-induced behavioral disinhibition [155, 170], rather than by lower anxiety, i.e., Lurcher mice have a reduced ability to inhibit exploration of a novel aversive environment (elevated plus maze) or novel object (rat)

PMC Mechanism)

It joins GSH to certain electrophilic compounds and oxidation products