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The main pitfalls include cost, access, side effects, and complications

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As NAD + is the precursor of NADH, the low levels of both metabolites suggest NAD + depletion while the NAD + /NADH ratio remained unchanged in most of the diseases (Fig

Acknowledgments We acknowledge Drugbank, SuperPred, PharmMapper, Therapeutic Target Database, Swiss Target Prediction, DisGeNET, PharmGKB, OMIM, and Genecards for providing their platforms and the contributors for uploading their meaningful datasets