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The highest dose of retatrutide helped patients lose 28.3% of their weight or 70.3 pounds on average over 80 weeks, compared with 2.2% with placebo, when evaluating only patients who stayed on the drug

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By noticing that the peptide did not show evidence of the ability to become lethal and was not toxic, researchers begin to look for ways that it could have a healing effect on rodent test subjects that had ileoileal anastomosis