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The hormone GLP-1 is also a neurotransmitter and communicates directly with an area in the brain that regulates appetite, called the hypothalamus

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So, the broader question is whether it is both clinically and economically better to aggressively treat certain high-risk obese patients sooner, or risk downstream cost and clinical complexity later

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More research is definitely needed, especially given the mortality rate associated with pancreatic cancer.17 There doesnt appear to be a direct link between pancreatic cancer and GLP-1 RA use at this time