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Orally administered Berberine modulates hepatic lipid metabolism by altering microbial bile acid metabolism and the intestinal FXR signaling pathway

Based on phase 2 inclusion criteria and the expected prescribing profile once approved, likely candidates include adults with BMI 30 kg/m or greater, adults with BMI 27 kg/m or greater with at least one weight-related comorbidity (per the obesity pharmacotherapy framework in the 2023 AHA/ACC/AAPA/ABC/ACPM/ADCES/AHNHA/AMA/ASH/ASPC/NHLBI/PCNA Guideline for Cardiovascular Risk Reduction) [16], and adults with biopsy-confirmed or imaging-confirmed MASLD or MASH where liver fat reduction is a treatment target

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