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UK Summaries of Product Characteristics (SmPCs) advise caution in people with a history of pancreatitis, severe gastrointestinal disease, or thyroid disease

The dosing is gradually titrated upward over several weeks to minimize gastrointestinal side effects

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Sommer F, Nookaew I, Sommer N et al (2015) Site-specific programming of the host epithelial transcriptome by the gut microbiota