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Genome-wide association studies (GWAS) coupled with metabolomic profiling has provided novel insights the role of inherited variation in blood metabolic diversity and potential opportunities for novel drug development in T2D (Shin S

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Apart from TRPC channels, a role for ionotropic glutamate receptors for Ca 2+ entry has been suggested: NMDA receptors permeable to Ca 2+ accomplish Ca 2+ homeostasis [102, 103], and also AMPA receptors may be relevant as pharmacological AMPA receptor antagonism blunts Ca 2+ entry into erythrocytes in response to Cl - removal [104]

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