Decreased levels of TNF- and IL-6 indicate that NNMT inhibition not only modulates metabolism but also improves the inflammatory microenvironment, a key component in metabolic disease development and insulin resistance
Potential Cartilage and Joint Support: Preliminary research has suggested that AOD-9604 may possess regenerative properties related to cartilage repair and joint health, independent of its metabolic effects
Retrieved May 3, 2025, from (Cautions that people with low blood pressure or a history of gout should not take niacin/niacinamide due to risk of hypotension and hyperuricemia
Liver Toxicity: Due to its oral nature, it can put a strain on the liver, potentially leading to liver damage or dysfunction.Hormonal Imbalances: It can suppress natural testosterone production and cause estrogenic effects like water retention and gynecomastia (male breast tissue enlargement).Androgenic Effects: Users may experience side effects such as acne, oily skin, and male-pattern baldness.Cardiovascular Issues: Use can lead to high blood pressure and negative changes in cholesterol levels, increasing the risk of heart disease and stroke
Research Overview# No human data -- All studies described below are preclinical (cell culture or animal models)