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Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimers disease
In vivo , HJG shortened swim times in the Morris Water Maze and increased phosphorylated CREB levels in A-injected Wistar rats, demonstrating its neuroprotective potential (Kubota et al., 2017)
Our CLP model showed chronic Nrf2/HO-1/GPX4 suppression (day 7) linked to GSH depletion, ferroptosis, and irreversible antioxidant collapse (Xie et al., 2020), supporting Nrf2 activators (e.g., sulforaphane) or GSH precursors (e.g., NAC) as interventions (Yusri et al., 2025)
Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory