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Opioid-induced esophageal dysfunction (OIED): Cases of OIED have been reported in patients taking opioids and may occur more frequently in patients taking higher doses of opioids, and/or in patients taking opioids longer term (see WARNINGS)

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The challenge was that natural incretins break down within minutes of release

Precautionary Principle: When long-term safety data is absent, especially for medications affecting metabolic function, regulatory bodies default to recommending avoidance during breastfeeding