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Miyagi M, et al

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This early fluid shift typically results in rapid scale changessometimes 5 to 10 pounds in the first monththat reflect water weight loss rather than fat reduction

Furthermore, adjustments to the regimen may be necessary based on how an individuals body responds to the medication

Retatrutide goes much further: GLP-1 appetite suppression GIP better nutrient handling Glucagon higher metabolic burn This combination means retatrutide can reduce body fat more aggressively while increasing resting energy expenditure something semaglutide does not directly influence