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PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024
View on PubMed Staresinic M, Petrovic I, Novinscak T, et al
In preclinical studies, NPI-001 has exhibited the ability to cross blood-brain and blood-retinal barriers
Should I follow any restrictions related to diet
Some individuals report better sleep quality and a slight uptick in energy levels during this phase, though these effects can vary widely
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