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Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG, et al

In fact, with the exception of the lowest treatment dose investigated (2.5 mg oral semaglutide), almost 100% of patients experienced a reduction in HbA 1c in the phase II trial, indicating that the variability in semaglutide exposure is not likely to affect the proportion of subjects with a clinically relevant treatment response [10]

I recommend simply testing it out for 6 months to one year

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Tropifexor (LJN452) is the most potent non-bile acid FXR agonist currently in clinical studies