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One successful trial, TRIUMPH-4, is not sufficient

Bariatric surgery, gastric devices, and low-efficacy pharmacological combinations shift from definitive solutions to second-line or situational options

HbA1c lowering effect The results of the clinical trials demonstrated significantly greater reductions in A1C with liraglutide compared to exenatide, and both GLP-1 receptor agonists caused greater reductions than those observed with sitagliptin [7] Data regarding these four agents from published head-to-head studies suggest that Liraglutide may have the largest A1C lowering capability, followed by dulaglutide, exenatide once weekly and then exenatide twice daily ( Figure 5 ) [8-10] GLP-1 RA are associated with an A1c reduction of 0.5-1.5% which is greater than 0.5-1% from DPP4 inhibitors the in head to head Duration clinical trials [11]

Diabetes Technology & Therapeutics, 24 (11), 789796

Regular weight monitoring and follow-up appointments to track changes and adjust management plans accordingly