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Le manifestazioni cliniche che ne conseguono configurano la cosiddetta malattia renale in corso di diabete ( diabetic kidney disease , DKD), caratterizzata da proteinuria selettiva e non selettiva, ipertensione arteriosa e declino progressivo della funzionalit renale

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Dermatologica Sinica, 41 (4), 199

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Besides, polyphenols also influence other mechanisms which tend towards improvement of muscle performance, for instance mitochondrial biogenesis comprises of two methods, either stimulating stress-related cell signaling pathways, increasing expression of genes encoding cytoprotective proteins such as nuclear respiratory factor 2 (NRF2) where variants of the NRF2 gene have been associated with endurance performance, or modulating muscle function and mitochondrial biogenesis by upstream regulation of sirtuins (SIRT1) and peroxisome proliferator-activated receptor coactivator (PGC-1) activity (Somerville et al