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Interestingly, this effect seems to be mediated through hepatic glucagon signalling, as infusion into the portal vein induced a satiating response whereas infusion into the inferior vena cava did not (64)
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FIGURE 1 3 Pharmacology and central nervous system mechanisms The therapeutic potential of semaglutide within the central nervous system (CNS) is intrinsically associated with the distribution and function of its target, the glucagon-like peptide-1 (GLP-1) receptor, as well as the drugs distinctive pharmacological properties that influence its interaction with the brain