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Theoretical or longer-horizon concerns Long-term human safety data for high-dose injectable NAD+ remains limited

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in Cell Metabolism note that SIRT1 activation improves mitochondrial efficiency and promotes a shift toward lipid utilization for energy, which can be especially beneficial in endurance and fat-loss settings (Price et al., Cell Metabolism )

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But when we want healing, specifically when you want to reduce inflammation a lot, we will use more ice