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Based on the literature, ligands of the transferrin, insulin and leptin receptors, and low density lipoprotein receptor-related proteins (LRPs) are used to shuttle pharmaceutical agents across the BBB in preclinical studies [18, 28]
Elsby R, Kitteringham NR, Goldring CE, Lovatt CA, Chamberlain M, Henderson CJ et al
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It is long known that cobalamin binds thiols through a strong and stable interaction of the formal cobalt(III) center with the thiolate anion of several biothiols such as glutathione [66]
Y.HassanniaB.BayirH.KaganV
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