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42 (1), 1531 (2016) M

Evidence from the pre- and postpartum periods was considered to avoid controversy raised by consideration of only limited evidence of risks during the prepartum period

Iwai S, Sueki H, Watanabe H, Sasaki Y, Suzuki T, Iijima M

Overall, experience from the oncology field suggests that amino acid metabolism intervention is more likely to be implemented through well-defined clinical development strategies, including monotherapy or combination therapy, dose escalation, safety monitoring, and immune pharmacodynamic endpoints, and may provide a useful framework for trial design and stratification in immune-mediated diseases

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