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Following repeated oral exposure for 4 weeks (1.75, 7, 28 mg/kg/day), granulomatous inflammation was observed, characterised by infiltration of macrophages and occasional lymphocytes into terminal bronchioles and alveolar spaces

Aging disrupts this process through cell cycle arrest mediated by p53 and p21, which halt hepatocyte proliferation, particularly in chronic injury or disease

The medicine is designed to be administered less frequently than Wegovy and Zepbound with injections once a month or less, compared with current drugs weekly shots

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