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Research suggests that once you gain weight to a certain point, signals in your hypothalamus may become damaged, causing you to no longer sense the hormones linked to satiety

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However, this may reflect no more than its relative potency as a prostaglandin inhibitor: common therapeutic doses of 12gm/day reduce prostaglandin formation by ~50% in comparison to the more complete suppression by other tNSAIDs like ibuprofen [82]

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