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Recently, agonists of glucagon-like peptide-1 (GLP-1) receptor, designed based on the gut hormone GLP-1, have been developed as anti-obesity drugs and have demonstrated remarkable efficacy in treating both obesity and diabetes

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Moderate-intensity exercise appears particularly effective, with studies showing increased GLP-1 secretion in people with type 2 diabetes following exercise interventions

This mechanism operates entirely independently of GLP-1 pathways

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