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First, GLP-1RA can activate the first messenger adenylate cyclase (AC) after binding to the receptor, which stimulates an increase in the secretion level of the intracellular second messenger cyclic adenosine phosphate (cAMP) and subsequently activates the intracellular secondary messenger protein kinase A (PKA) (50), facilitating the release of calcium ions

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Mariana Matos, MD provided medical writing support on behalf of Springer Healthcare in accordance with Good Publication Practice (GPP3) guidelines