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The findings suggest that GPX7 protects esophageal cells from acid-induced oxidative damage and that patients with GPX7 dysfunction could be at higher risk of developing Barretts esophagus and, subsequently, esophageal cancer

Meanwhile, the levels of GPX4 and its cofactor GSH decreased, while the markers of labile iron content (Fe 2+ ) and lipid peroxidation product MDA increased significantly

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Real-world patients may be older, present with multiple comorbidities, receive concomitant medications, and face challenges related to healthcare access, adherence, and long-term disease management