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MASH improvement (no fibrosis worsening) at 2.4mg: 47% MASH improvement (no fibrosis worsening) at 4.8mg: 62% MASH improvement (no fibrosis worsening) at 6.0mg: 43% Placebo MASH improvement: 14% Liver fat reduction of 30%+ at 4.8mg: 67% Fibrosis improvement by 1+ stage: 34-36% These results led to FDA Breakthrough Therapy designation, which accelerates the development and review process for drugs addressing serious conditions

9-11 If a GLP-1 RA is determined to be the best option for the patient, pharmacists and providers should consider the following recommendations: Follow dosing recommendations as directed by the manufacturer

Arch Dis Child 99(11):10141019

This could lead to pulmonary aspiration, respiratory infections, and other life-threatening complications

Side effect comparison: Nausea: Similar rates between the two compounds Vomiting: Cagrilintide significantly lower (OR 0.38) Diarrhea: Comparable rates Constipation: Similar Injection site reactions: Cagrilintide substantially higher Discontinuation due to AEs: Cagrilintide much lower (1% vs approximately 5-7%) The takeaway: if vomiting was your main problem on semaglutide, cagrilintide may be worth exploring