Activation of Tissue Remodeling Proteases GHK-Cu activates matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in a balanced way that facilitates controlled extracellular matrix remodeling breaking down damaged collagen and replacing it with new, organized fibrillar collagen rather than scar tissue
Immunofluorescence staining was performed on the frozen cochlear cryosections of P3, P14, and P30 C57BL/6 mouse cochleae (Figure 1A), and Tuj 1, a neuron-specific marker which specifically labels both the cytoplasm and neurite of SGN, was used to mark SGN
References Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Wei M, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD: Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans
Your journey is personal
MzesFELeeJASelvarajEAJayaswalANATraunerMBoursierJet al