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Downregulation of ASCT2 in EC cells induces cell cycle arrest and apoptosis, and significantly reduces cell growth by blocking Gln transport [26]

22,23 Since IGF-1R governs PI3K/AKT and Ras/ERK signaling pathways, 1 we next to test whether induction of p70S6K1 phosphorylation is dependent on K-Ras or PIK3CA mutation

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W., Sorenson, S