Bottomline: Methylcobalamin vs
Betaine supplementation has been used for over 40 years to support individuals with genetic defects of folate dependent remethylation because betaine is known to increase methionine concentration and aid homocysteine reduction
When joint discomfort occurs after starting B12, it is typically coincidental or related to other factors such as excipients in formulations, injection-site effects, pre-existing musculoskeletal conditions, or rare hypersensitivity reactions rather than a direct effect of the vitamin itself
Yet many peopleespecially in colder climates or with indoor lifestylesare deficient without even knowing it
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