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The doses used in compounded formulations are typically low, and whether they provide meaningful benefit is unclear

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J Inherit.Metab Dis 2006;29(2-3):288-298

Pharmaceutics, 16(9), 1132

The reduction of cardiovascular events is not only related to anti-diabetic properties, but also to pleotropic effects leading to the reduction of the residual cardiovascular risk, that has been defined as the risk of progression of CV events (MACE or HF) that remains after the optimal glycaemic control in T2DM patients, and it seems to be related to meta-inflammation, defined as a low-grade chronic and sterile inflammatory status