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The doses of liraglutide or semaglutide are different depending on whether the patient has DT2, is overweight (BMI 27kg/m2) with comorbidities or has obesity (with or without DT2)

The substitution of carboxamide at the alkyl terminal (KL2, KL4 and KL5) or removal of the nitrile group from the dihydropyridine ring (KL6) moderately reduced their adjuvant activity (Extended Data Fig

Both drugs are intended for short-term use

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