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Additionally, weight loss is generally seen as having a definitive endpoint, leading users to (rightly or wrongly) expect that their treatment can be tapered down or discontinued once their goal is achieved

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Dipeptidyl peptidase 4 cleaves the penultimate prolines or alanines of peptides' N-terminal regions, such as GIP and GLP, effectively inactivating these peptides

Am J Kidney Dis 1998