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In addition to supporting energy levels, vitamin B12 is crucial for healthy nervous system function and cognitive health, which can further contribute to improved mood and mental clarity

People with mitochondrial diseases should consult a specialist before using any compound that alters mitochondrial function

Alternatively, it can be mixed with water or juice before consumption.

The MTHFR enzyme is responsible for converting tetrahydrofolate into 5-methyltetrahydrofolate (5-MTHF), and reduced enzyme activity may influence methylation efficiency, particularly if riboflavin (vitamin B2) status is suboptimal

Toxicol Sci 2014;138:139-47