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Mellouki I, Meyiz H (2013) Melanosis coli: a rarity in digestive endoscopy

furthermore, lycopene not only prevented the smoking-induced decrease in p21 waf1/cip1 , proapoptotic protein Bax-1 and cleaved caspase 3 but also reversed the increase in the cell proliferation markers including cyclin D1 and PCNA, suggesting that lycopene protects the gastric mucosa from smoking-induced damage through p53-dependent cell cycle control and apoptosis, and may counteract the development of gastric cancer associated with smoking (Liu et al., 2006) (Figure 3)

Also avoid doubling up after a missed dose

Patients may require a lower dose of the secretagogue or insulin to reduce the risk of hypoglycemia in this setting [see Adverse Reactions (6.1), Drug Interactions (7.1)]

This could be as simple as walking or doing household chores