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Intriguingly, OWL-833 has a similar signalling and regulatory profile to that of TT-OAD2, where neither agonist promoted -arrestin recruitment or internalisation and both were also very poor agonists for pERK1/2 and calcium mobilisation
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These medications also require caution in people with a personal or family history of medullary thyroid cancer or MEN2, history of pancreatitis, significant gallbladder disease, severe gastroparesis, or active eating disorder concerns
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Additionally, GLP-1 receptors are expressed in the dorsal root ganglion and peripheral nerves (5053) and in a T1DM animal model, GLP-1 treatment led to intraepidermal nerve fiber regeneration without a change in weight or glucose (20)
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