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The molecule has a very high affinity for copper (II) and forms the chelate GHK-Cu

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Accessed 10/6/2025, Barsan ME

Concurrently, GHK-Cu downregulates pro-inflammatory cytokines (IL-6, TNF-alpha), pro-fibrotic mediators, and several metalloproteinases involved in excessive tissue degradation

Relative mRNA expression of Gclm (p = 0.0026), Hmox1 , Nqo1 , and Slc7a11 (d) and representative immunohistochemistry of indicated proteins (e) in Gclc WT and Gclc KO tumors (n = 6 representative from 3 independent experiments)