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The NHS generally recommends a gradual weight loss of 0.5-1 kg per week as being more sustainable and potentially less likely to result in significant skin laxity

This is one of the most important (and often overlooked) pieces of the puzzle, especially when it comes to preventing relapse

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15,16 Chronic cardiovascular, lung and liver diseases have been shown to have low levels of glutathione which impact severity of disease

Additional safety considerations include: Cardiovascular risk: Both medications require caution in patients with cardiovascular disease