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Apart from increasing the binding affinity of GLP-1, compound 2 also acts as an agonist on its own, thereby being classified as an ago-allosteric modulator (ago-PAM) of GLP-1R 25,28

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In that same study, 29% of people taking metformin daily lost greater than or equal to 5% or more of their initial body weight by the end of the first year, compared with 13% of people in the placebo group