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Similarly, resistance to oxidative attack increased after overexpression of GPX5 in CHO-K1 cells, and GPX5 overexpressing cells reduced lipid peroxidation levels and downstream DNA damage marker 8-OXODG levels compared to control cells (Taylor et al., 2013)

Digestion (2011) 84:1221

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It was found that the use of inhibitors of ferroptosis could reduce cigarette smoke-induced cell death, suggesting that ferroptosis plays an important role in cigarette smoke-induced trophoblast cell death and may contribute to miscarriage ( 5 Pathophysiological mechanism 5.1 Molecular mechanisms of ferroptosis Ferroptosis is a regulated form of cell death characterized by iron-dependent lipid peroxidation and oxidative stress, playing a significant role in RM through trophoblast dysfunction