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This deficiency is primarily associated with food-bound malabsorption and a diet lacking in vitamin B-12, which is found mainly in meat, eggs, and milk

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Dysesthesia occurred in 5.1% (4 mg), 12.3% (9 mg), and 12.5% (12 mg) of patients treated with retatrutide, compared to 0.9% with placebo, although this was generally mild to moderate and resolved during treatment

This mechanistic hypothesis underpins the substantial weight loss signals observed in early trials, though the precise contribution of each receptor pathway in humans remains an active area of investigation