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Published 2022 Mar 15

Oral medications with narrow therapeutic indices require particular attention

Excessive caffeine or energy drinks: Large amounts of caffeine may raise stress hormones and oxidative stress, reducing the effectiveness of supplementation

Prolonged deficiency can cause irreversible nerve damage, leading to balance and coordination problems

Animal studies further indicate that chronic paternal exposure to anabolicandrogenic steroids prior to conception may alter sperm-borne epigenetic signatures and adversely affect fertility-related outcomes in offspring, although direct evidence in humans remains limited and requires further investigation (80)