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At a creatinine clearance of 15 to 29 mL/min, the recommended total daily dose drops to 200 to 700 mg [3]

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In contrast to an earlier study that also found such matched contralateral lesions (Werring et al., 2000), this more recent report detected such mirror precursory lesions well before a T2 lesion formed in the index hemisphere, precluding the previous explanation of axonal transection and Wallerian degeneration as a possible contributor to the contralateral mirror abnormality