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methylmalonic acid and homocysteine require vitamin B 12 as a cofactor for enzymatic conversion, and either or both may be elevated in early vitamin B 12 deficiency

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While treatment-emergent HLA antibodies are likely to be reduced by the use of leukocyte-reduced RBCs in both Test and Control arms, we hypothesize that inactivation of residual leukocytes by the amustaline/GSH pathogen reduction process might affect the incidence of alloimmunization

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Gentinetta S et al