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During the peak of the COVID-19 pandemic, preexisting conditions like diabetes and metabolic problems dramatically increased the health risks for infected patients, more than tripling the risk of hospitalization for obese patients 18 and younger

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Concerns include reports of adverse events, some requiring hospitalization, that may be related to dosing errors or doses beyond what is in the FDA-approved drug label, which means using more product in a single dose, taking doses more frequently or increasing the amount more quickly (titration schedule)