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The C-terminal rhodanese domain of CstB also displayed a similar fold with the human rhodanese (sulfurtransferase TSTD1) despite a meager 23 % sequence identity (Fig

Results Induction of localized BDNF reduction We designed four different sequences of shRNAs complementary to the coding exon of the rat BDNF gene, that is common to all isoforms of this gene, 28 and then tested which sequence most effectively reduces BDNF levels in vitro (Supplementary Figure 1)

J Am Chem Soc 126:1645616465 [DOI] [PubMed] [Google Scholar] Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J (2004) Role of oxygen radicals in DNA damage and cancer incidence

The study also confirmed that exercise induces endogenous MOTS-c production in human skeletal muscle, establishing a bidirectional relationship between MOTS-c and physical activity (Reynolds JC et al., Nat Commun