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It is a plausible mechanism via which GLP-1 may lead to intake suppression since activation of GLP-1 via EX4 injection was shown to decrease the motivation to obtain food (Dickson et al., ad libitum fed rats indicating that this response is robust (Dickson et al., ad libitum condition in which some rats still choose to expend a significant amount of work for their sugar reward (high-responders)

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