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They concluded that incretin-based medications did not correlate with an increased risk of acute pancreatitis or pancreatic cancer compared to other oral anti-diabetic agents, which remained consistent across drug classification and duration of use [29,55]

Canadian Journal of Diabetes 2018 Canadian Diabetes Association

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10.1210/clinem/dgae719 [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Horowitz M, Rayner CK, Marathe CS, Wu T, Jones KL (2020) Glucagon-like peptide-1 receptor agonists and the appropriate measurement of gastric emptying

From 1924 several researchers began to investigate the effect of injected and orally administered duodenal (secretin) extracts on fasting blood glucose levels and hyperglycemia (high blood sugar) in normal and diabetic animals and humans