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Studies that used 1 mg/day in oral and intravenous trials did not show meaningfully better outcomes than lower doses, and higher doses were associated with more reports of headache, diarrhea, and gastrointestinal effects

Even if the medicine is thawed later, it will not return to its original form

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Other migraine-related parameters such as severity and frequency were not assessed

If this translates clinically, it could explain signals across alcohol, nicotine, opioids, and other substances